Effect of quinidine on plasma concentrations of digoxin.

Abstract

Case 2A 74-year-old woman weighing 48 kg was admitted for a simple mastectomy 14 months after advanced carcinoma of the breast had been treated by radiotherapy.She was in good general health, her only complaint being dyspnoea on exertion.Examination showed a pansystolic murmur, which was attributed to mild mitral incompetence.Arterial pressure was 180/ 65 mm Hg.There was no evidence of cardiac failure, but an electrocardio- gram contained some evidence of myocardial ischaemia.Haemoglobin was 12 1 g/dl; serum urea and electrolyte concentrations were normal.Drug