Proceedings of the National Academy of Sciences · 1971 · 106 citations · 8 references
Life SciencesImmunologyOncologyCancer ImmunologyCellular ImmunologyTumor ImmunologyAntitumor T Cell ResponsesCancer ImmunotherapyCell-mediated ImmunityCytotoxic T Lymphocyte ResponsesImmunotherapy For Solid TumorsT Cell Responses To TumorsAntigen-specific Immune ResponseImmune Cell Surface ModificationImmunogenicity Of Tumor AntigensSyngeneic Tumor ModelsT Cell CytotoxicityT Cell-mediated CytotoxicityTherapeutic Cancer ImmunizationTumor Immunogenicity
The immunogenicity of the EL-4 strain of mouse lymphoid leukemia cells in syngeneic C57BL/6 recipients was enhanced by in vitro coating of the cells with either Concanavalin A or dinitrophenylaminocaproate. The tumor-specific immune response was quantitated using a recently developed assay that involves in vitro cell-mediated cytotoxicity.
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Quantitative in vitro assay of cytotoxic cellular immunity.
Timothy G. Canty, John R. Wunderlich · PubMed · 1970 · 191 citations