Effect of Glutathione Depletion and Hydrophilic Bile Acids on Hepatic Acute Phase Reaction in Rats with Extrahepatic Cholestasis

Abstract

We show that GSH is involved in the acute phase reaction during obstructive cholestasis. In addition, bile acids might selectively ameliorate the acute phase response by reducing expression of the APP not affected by GSH depletion (alpha2-macroglobulin and TIMP-1).