Supramolecular Catalysis in the Organic Solid State through Dry Grinding

Abstract

Chemical mechanics: Hydrogen-bond-driven self-assembly and mechanochemistry are used to facilitate supramolecular catalysis in the solid state. Mortar-and-pestle grinding proves to be an efficient means to achieve co-crystal formation and turnover using a physical mixture composed of an olefin and catalytic amounts of a ditopic template (see scheme).