High-Voltage Electrophoresis in Urinary Amino Acid Screening

Abstract

High-voltage electrophoresis at two different pH's of amino acids in urine is described. The method was used for screening mentally retarded patients and patients with neurological disorders. The aminoacidopathies detected in the material were phenylketonuria, homocystinuria, histidinemia, cystin uria, normoglycinemic glycinuria, and cases with increased histidine ex cretion. The excretion of ampicillin-produced spots was observed in patients with ampicillin medication.