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Binding of Folic Acid to Serum Proteins
11
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0
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1974
Year
ImmunohematologyElectrolyte DisorderUntreated Pernicious AnaemiaBioanalysisHematologyNeurologyClinical ChemistryLaboratory MedicineProteomicsFolic Acid ActivityHealth SciencesProtein ChemistryNutrient PhysiologyProtein FunctionBiochemistryInherited Metabolic DiseaseClinical NutritionZone IiPharmacologyClinical DisordersPhysiologyNutritional NeuroscienceBiological FunctionFolic AcidMetabolismMedicineLysosomal Storage Disease
In untreated pernicious anaemia, the binding of folic acid activity (FAA) to protein zone II of the serum (transferrin) had increased distinctly and to zone I (γ-globulin) slightly. A decrease, on the other hand, was noted in zones IV-V (α2-macroglobulin and albumin). During specific treatment, the changes return to normal, with FAA diminishing in zone II and increasing in zones IV-V. There were still some changes present after 7 weeks of treatment, when the anaemia had already been cured. In a pernicious anaemia patient with neuropathy the chromatogram was not much different from normal, and a slight increase in FAA was noted during treatment in protein zones, I, II and IV.