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Studies on the Synthesis of the 1-Hydroxynortropane System; Part II.<sup>1</sup>Synthesis of Calystegine A<sub>3</sub>and Physoperuvine
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1992
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BiosynthesisEngineeringHeterocyclicBiochemistryRacemic Calystegine A3Cyclisation ProductsBiocatalysisNatural SciencesOrganic Chemistry4-Aminocycloheptanones 7,8Synthetic ChemistryChemistryNatural Product Synthesis1-Hydroxynortropane SystemBiomolecular Engineering
Total syntheses of racemic calystegine A3 {8-azabicyclo-[3.2.1)octane-1,2,3-triol (3)} and physoperuvine {8-methyl-8-azabicyclo[3.2.1]octan-1-ol (4)} are described using intramolecular cyclisation of 4-aminocycloheptanones 7,8. Influence of the substituents on the stability of the cyclisation products is investigated.