[Cu(acac)₂]⋅<b>H₂O‐Catalyzed Sonogashira‐Type Couplings of Aryl Halides and Terminal Alkynes</b>

Abstract

Highly selective coupling of aryl halides with terminal alkynes can be conducted using low-cost and readily available [Cu(acac)2]⋅H2O under palladium- and amine-free conditions. This protocol makes the typical Sonogashira reaction more practical and useful (TBAB=tetrabutyl ammonium bromide; DMSO=dimethyl sulfoxide; see scheme).