Bactericidal/Permeability-Increasing Protein Attenuates Systemic Inflammation and Acute Lung Injury in Porcine Lower Limb Ischemia–Reperfusion Injury

Abstract

Endotoxin transmigration across a hyperpermeable gut barrier, phagocytic cell priming, and cytokinemia are key events of I/R injury, sepsis, and pulmonary dysfunction. This study shows that rBPI21 ameliorates these adverse effects and may provide a novel therapeutic approach for prevention of I/R-associated sepsis syndrome.