Human Skin and Gingival Keratinocytes Show Differential Regulation of Matrix Metalloproteinases When Combined With Fibroblasts in 3‐Dimensional Cultures

Abstract

Varying the type of fibroblast beneath the keratinocytes allowed us to determine that skin and gingival keratinocytes differentially regulate the production and activation of MMP-9, but not MMP-2, a finding that could influence the success of tissue grafting after periodontal surgery.