American Journal of Alzheimer s Disease & Other Dementias® · 2008 · 37 citations · 15 references
Life SciencesNeurologyNeuroscienceDementiaNeurobiology Of DiseaseNeurodegenerationAlzheimer DiseaseDementia With Lewy BodiesLewy Body DementiaNeurodegenerative DiseasesNeurodegenerative DisordersNeuropathology Of DementiaAlzheimer Disease DementiaAlzheimer Disease ProgressionBraak StagingCognitive Status AssessmentCorrelationNeuritic PlaquesSynaptic LossSynaptic Pathology
Synaptic loss is present in Alzheimer's disease and correlates with the severity of dementia. Loss of synapses in dementia with Lewy bodies (DLB) does not correlate as clearly with cognitive status and its cause is unclear. To begin to understand the relationship between cognition and synaptic loss in DLB, we assessed immunoreactivity for the synaptic-terminal specific protein, synaptophysin, in the hippocampus in 14 DLB cases. Quantitative synaptic data were obtained using an Image-Pro semiautomated analysis system. We determined Braak stage, beta-amyloid, Lewy bodies (LBs), and Lewy neurites (LN). We found significant correlations (r = 0.617, P < .01) between Braak stage and synaptophysin score and marginal correlation between LN score and synaptophysin loss ( r = 0.694, P < .06). Correlations of beta-amyloid and of LB density with synaptophysin score were unimpressive. These data support the hypothesis that synaptic loss in DLB is related to neuritic degeneration.
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Synaptic loss in Alzheimer's disease and other dementias
James E. Hamos, Louis J. DeGennaro, David A. Drachman · Neurology · 1989 · 454 citations
Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies
Annette Merdes, Lawrence A. Hansen, D. V. Jeste et al. · Neurology · 2003 · 324 citations