TRAFFICKING OF HOST- AND DONOR-DERIVED DENDRITIC CELLS IN RAT CARDIAC TRANSPLANTATION: ALLOSENSITIZATION IN THE SPLEEN AND HEPATIC NODES1

Abstract

We conclude that allogeneic heart transplantation induces the recruitment of host DC precursors to the graft tissues and the blood-borne migration of both recruited host and donor DCs to the host spleen and hepatic nodes where effector cells are predominantly sensitized.