Immunohistochemical Localization of Vascular Endothelial Growth Factor, Transforming Growth Factor α, and Transforming Growth Factor β1 in Human Corneas with Neovascularization

Abstract

The angiogenic factors VEGF, TGFalpha, and TGFbeta1 are detectable in human corneas with neovascularization. Their distribution is quite uniform in different corneal diseases, resulting in corneal angiogenesis. An antiangiogenic therapy inhibiting corneal neovascularization by antagonizing angiogenic factors would have to counteract several angiogenic factors.