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An efficient 3(C)-acylation of tetramic acids involving acyl migration of 4(O)-acylates.

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References

1987

Year

Abstract

3 (C) -Acylation of 3-unsubstituted tetramic acids with carboxylic acid has been achieved by two sequential reactions in one flask : (1) 4 (O) -acylation in the presence of DCC and a catalytic amount of DMAP, and (2) 4 (O) →3 (C) acyl-migration promoted by adding Et3N.