Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds

Abstract

Abstract In the present work, we investigated a first generation of a new dendrimer as candidate for intravenous (iv) administration of a therapeutic compound (2′‐(benzo[1,2‐c] 1,2,5‐oxadiazol‐5(6)‐yl (N‐1‐oxide) methylidene]‐1‐methoxy methane hydrazide). This compound presents antichagasic activity but low water solubility. Guest–host specific interactions results in good drug solubilization. These interactions can be controlled by varying the solution pH, allowing drug deliverance. Interaction between dendrimer and human serum albumin (HSA), and the hemolytic potential of dendrimer were evaluated. The dendrimer does not interact with blood proteins, is not hemolytic, and does not produce damage in the cellular membrane. The results demonstrate that the new dendritic structure could be an appropriate carrier for the novel antichagasic drug. Copyright © 2008 John Wiley & Sons, Ltd.