The Effects of Sevoflurane on Serum Creatinine and Blood Urea Nitrogen Concentrations: A Retrospective, Twenty-Two–Center, Comparative Evaluation of Renal Function in Adult Surgical Patients

Abstract

Our data for changes in serum creatinine and blood urea nitrogen indicate that, for exposures of less than 4 minimum alveolar anesthetic concentration/h, sevoflurane is not associated with an increased risk of renal toxicity compared with other commonly used anesthetics. For clinical purposes, the pre- to postoperative changes in serum creatinine and blood urea nitrogen are appropriate measures of renal function in surgical patients.