The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver - Concepedia

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The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver

34

Citations

12

References

2010

Year

Yoshitaka Hasegawa, S Kishimoto, Naoki Shibatani, Hiromichi Nomura, Yuko Ishii, Mika Onishi, Nobuo Inotsume, Yoshikazu Takeuchi, Shoji Fukushima

Journal of Pharmacy and Pharmacology

Abstract

In STZ-diabetic rats, the distribution volume of morphine increased, the glucuronidation rate and M3G transportation into the blood were enhanced, and the excretion of M3G was decreased, leading to an increase in the plasma M3G concentration.

References

	Year	Citations

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