Selective Cyclooxygenase-2 Inhibition Reverses Microcirculatory and Inflammatory Sequelae of Closed Soft-Tissue Trauma in an Animal Model

Abstract

Treatment of skeletal muscle soft-tissue trauma with parecoxib before as well as after injury is highly effective in restoring disturbed microcirculation. Moreover, a reduced inflammatory cell response helps to prevent leukocyte or platelet-dependent secondary tissue injury. These results deserve further investigation to prove that selective COX-2 inhibitors improve performance and promote healing following closed soft-tissue injury.