Role of endotoxin and nitric oxide in the pathogenesis of renal failure in obstructive jaundice

Abstract

Endotoxaemia in obstructive jaundice may induce overproduction of nitric oxide that may lead to impairment of cGMP-associated vasodilatation and disrupt autoregulation of the renal vascular bed. This may contribute to renal failure in obstructive jaundice.