Publication | Open Access
A novel mode of FoxM1 regulation: Positive auto-regulatory loop
119
Citations
0
References
2009
Year
Chemoprevention StrategyGeneticsGene Regulatory NetworkTumor BiologyFoxm1 RegulationAnti-cancer AgentRadiation OncologyCell SignalingOncogenic AgentFoxm1 InhibitorsThiazole AntibioticsGene ExpressionPharmacologyTumor MicroenvironmentTranscription RegulationAttractive Therapeutic TargetGene RegulationTumor SuppressorMedicineDrug Discovery
Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisingly, investigation of the mechanism of action of FoxM1 inhibitors revealed a novel mode of positive auto-regulation of FoxM1.