The Effect of Sevoflurane and Isoflurane Anesthesia on Interictal Spike Activity Among Patients with Refractory Epilepsy

Abstract

The results of this study suggest that the capacity to modulate neuroexcitability is a dose-dependent feature of volatile anesthetics that is manifested most prominently at near burst-suppression doses (i.e., 1.5 times the minimum alveolar anesthetic concentration) and is minimal or absent at low doses.