Wirkstoffe aus Pilzen, I. Isolierung, Synthese und biologische Wirkung von Coniothyriomycin sowie Synthese und Biotestung analoger offenkettiger Imide

Abstract

Biologically Active Metabolites of Fungi, I. — Isolation, Synthesis, and Biological Activity of Coniothyriomycin as well as Bioassay of Analoguos Open‐Chain Imides The mixed open‐chain imide N ‐(3‐chloro‐4‐hydroxyphenyl‐acetyl)fumarate ( 1 ), named coniothyriomycin, was isolated as metabolite of the fungus Coniothyrium . The natural product 1 and the analoguos imides 13 – 15 and 22 – 24 have been synthesized by base‐catalyzed condensation of the imidates 12a – f with acid chlorides 6a – c or the mixed anhydride 21 . The compounds 1 and 13 – 15 were shown to posess remarkable fungicidal and herbicidal activities in short‐termed tests.