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Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition

Increased Inhibitory ActivityMedicinal ChemistrySignal TransductionBiochemistryMedicineNatural SciencesReceptor Tyrosine KinaseDimeric DerivativeChemical BiologyPharmacologyCell SignalingProtein PhosphorylationDrug DiscoveryDual-specificity Erk Phosphatase