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Trypanocidal Effects of Curcumin in Vitro.
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1998
Year
Medicinal ChemistryAntifungal AgentAfrican TrypanosomiasisMedicineAntiparasitic AgentAfrican TrypanosomesImmunologyParasitic ProtozoaPathologyPhytopharmacologyToxicologyPharmacotherapyTrypanosoma Brucei BruceiTrypanocidal EffectsNatural CompoundsPharmacologyDrug DiscoveryDrug Resistance
During the course of study searching for the antiparasitic agents from natural compounds, we found that curcumin showed cytotoxicity against African trypanosomes in vitro. The LD50 values of curcumin were 4.77 +/- 0.91 microM for bloodstream forms and 46.52 +/- 4.94 microM for procyclic forms of Trypanosoma brucei brucei (GUTat 3.1 clone).