Bulletin of the Chemical Society of Japan · 1989 · 61 citations · 4 references
Natural SciencesChemistryOrganic ChemistryOrganic SynthesisPyrrole ChemistryPyrrole Synthesis
Abstract 4-Alkyl-3-trifluoromethyl-2-pyrrolecarboxylic acid esters (2) were conveniently prepared by the reaction of trifluoromethylated β-nitro acetates (1) with ethyl isocyanoacetate. The pyrroles were converted into the corresponding porphyrins via tetramerization of 2-(hydroxymethyl)pyrroles.
4
Synthesis of β-trifluoromethylpyrroles
Hisanobu Ogashi, Michihide Homma, Kazuhiko YOKOTA et al. · Tetrahedron Letters · 1983 · 23 citations