A Convenient Synthesis of Trifluoromethylated Pyrroles and Porphyrins

Abstract

Abstract 4-Alkyl-3-trifluoromethyl-2-pyrrolecarboxylic acid esters (2) were conveniently prepared by the reaction of trifluoromethylated β-nitro acetates (1) with ethyl isocyanoacetate. The pyrroles were converted into the corresponding porphyrins via tetramerization of 2-(hydroxymethyl)pyrroles.