Association between polymorphisms in<i>SOD1</i>and noise-induced hearing loss in Chinese workers

Abstract

Genotype AA of rs2070424 conferred protection against NIHL (adjusted OR = 0.45, p = 0.005), while GG of rs10432782 was a risk genotype (adjusted OR = 1.88, p = 0.026). One protective haplotype TATG (OR = 0.56, p = 0.003) and two risk haplotypes, CATG and TGGA (OR = 1.58, 28.75 and p = 0.017, <0.001, respectively) were identified. Significant interactions between SOD1 SNPs and noise levels were found. Further analysis of effects of SOD1 SNPs found that those carrying GG genotype of rs10432782 had significantly higher SOD1 activity (p = 0.022), but a significantly lower level of malondialdehyde in plasma, compared with TT carriers (p = 0.007).