Low-Dose Splenic Irradiation in the Treatment of Autoimmune Thrombocytopenia in HIV-infected Patients

Abstract

Brief Reports15 February 1992Low-Dose Splenic Irradiation in the Treatment of Autoimmune Thrombocytopenia in HIV-infected PatientsSamuel W. Needleman, MD, James Sorace, MD, Hipolito Poussin-Rosillo, MDSamuel W. Needleman, MDSearch for more papers by this author, James Sorace, MDSearch for more papers by this author, Hipolito Poussin-Rosillo, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-4-310 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAutoimmune thrombocytopenic purpura (AITP) is one of many compli-cations associated with human immunodeficiency virus (HIV) type-1 infections (1, 2). Circulating immune complexes (3), antiplatelet antibodies (4, 5), and anti-idiotype antibody formation (6) have each been suggested to play a role in its pathogenesis.Treatment of AITP in HIV-infected patients is difficult for two reasons. Established therapies for AITP (that is, corticosteroids) may be associated with an increased risk in patients with HIV infection because they superimpose an additional immunosuppressive burden and thus might increase the rate of opportunistic infection (7). Splenectomy, although offering remission rates in HIV-infected patients comparable to...References1. Karpatkin S. HIV-1-related thrombocytopenia. Hematol Oncol Clin North Am. 1990;4:193-218. CrossrefMedlineGoogle Scholar2. Aboulafia D and Mitsuyasu R. Hematologic abnormalities in AIDS. Hematol Oncol Clin North Am. 1991;5:195-214. CrossrefMedlineGoogle Scholar3. Walsh C, Nardi M, and Karpatkin S. On the mechanism of thrombocytopenic purpura in sexually active homosexual men. N Engl J Med. 1985;311:635-9. CrossrefGoogle Scholar4. Strieker R, Abrams D, Corash L, and Shuman M. Target platelet antigen in homosexual men with immune thrombocytopenia. N Engl J Med. 1985;313:1375-80. CrossrefMedlineGoogle Scholar5. Savona S, Nardi M, Lennette E, and Karpatkin S. Thrombocytopenic purpura in narcotic addicts. Ann Intern Med. 1985;102:737-41. LinkGoogle Scholar6. Yu J, Lennette E, and Karpatkin S. Anti-F(ab')2 antibodies in thrombocytopenic patients at risk for acquired immunodeficiency syndrome. J Clin Invest. 1986;77:1756-61. CrossrefMedlineGoogle Scholar7. Shafer R, Offit K, Macris N, Horbar G, Ancona L, and Hoffman I. Possible risk of steroid administration in patients at risk for AIDS [Letter]. Lancet. 1985;1:934-5. CrossrefMedlineGoogle Scholar8. Pirofsky B. Immune haemolytic disease: the autoimmune haemolytic anaemias. Clin Haematol. 1975;4:167-80. CrossrefMedlineGoogle Scholar9. Wolf B and Neiman R Hyposplenism. In: ; eds. Disorders of the Spleen. Philadelphia: W.B. Saunders; 1989:39-49. Google Scholar10. Robinette C and Fraumeni J. Splenectomy and subsequent mortality in veterans of the 1939-45 war. Lancet. 1977;2:127-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Samuel W. Needleman, MD; James Sorace, MD; Hipolito Poussin-Rosillo, MDFrom the University of Maryland Hospital and the Baltimore Depart ment of Veterans Affairs Medical Center, Baltimore, Maryland. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComparison of partial splenic embolization versus splenic irradiation as a treatment of hypersplenism in advanced cirrhosisSplenic Radiation and Double-Filtration Plasmapheresis in Crossmatch-Positive Live Renal TransplantationHIV-related thrombocytopeniaDetrimental Effects of High-Dose Dexamethasone in Severe, Refractory, HIV-Related ThrombocytopeniaSplenic irradiation versus splenectomy for severe, refractory HIV-related thrombocytopenia: effects on platelet counts and immunological statusThe role of splenic irradiation in treating HIV-associated immune thrombocytopeniaLow-Dose Splenic Irradiation in the Treatment of Immune Thrombocytopenia in HIV-Infected PatientsSplenic irradiation in HIV-related thrombocytopeniaEffect of Low-Dose Gamma Radiation on HIV Replication in Human Peripheral Blood Mononuclear CellsLow-dose splenic irradiation in human immunodeficiency virus-related immune thrombocytopeniaHematologic manifestations and malignancies of children with HIV infection 15 February 1992Volume 116, Issue 4Page: 310-311KeywordsCareers in researchHematology and oncologyHIVHIV infectionsIdiopathic thrombocytopenic purpuraImmune complexImmunosuppressivesOpportunistic infectionsPathogenesisSplenectomy ePublished: 1 December 2008 Issue Published: 15 February 1992 PDF downloadLoading ...