Achyrofuran, a New Antihyperglycemic Dibenzofuran from the South American Medicinal Plant <i>Achyrocline </i><i>s</i><i>atureioides</i>

Abstract

A new prenylated dibenzofuran, achyrofuran (2), was isolated from an extract of Achyrocline satureioides by bioassay-guided fractionation using the db/db mouse model for type 2 diabetes. Compound 2significantly lowered blood glucose levels in this model when administered orally at 20 mg/kg q.d.