The constitution and properties of two gastrins extracted from hog antral mucosa

Abstract

EDITORIAL SYNOPSIS This paper is the culmination of many years' work on the detection, isolation, physiological study, and now, large-scale production of gastrin. The final product has been identified as two almost identical peptides (gastrins I and II). Both are many times more potent than histamine in stimulating gastric acid secretion. Secretion may be inhibited if the dose administered is large. This duplex effect (stimulation in low concentration, inhibition in high concentration) has other pharmacological parallels such as the effect of nicotine on ganglionic transmission. This very important paper is likely to have many repercussions in clinical practice.