Extracellular Signal-Related Kinase 1/2 and p38 Mitogen-Activated Protein Kinase Pathways Serve Opposite Roles in Neutrophil Cytotoxicity

Abstract

Activation of p38 MAPK promotes superoxide release from PMNs activated by f-Met-Leu-Phe. The ERK1/2 pathway may serve as a negative feedback mechanism for granule exocytosis.