Reaction of benzyne with 1,2,5-thiadiazoles and 2,1-benzisothiazoles

Abstract

1,2,5-Thiadiazoles react with benzyne to give 1,2-benzisothiazole derivatives. 3,4-Diphenyl-1,2,5-selenadiazole with benzyne likewise affords 3-phenyl-1,2-benzisoselenazole, contrary to a previous report. Some reactions of 3-(8-cyano-1-naphthyl)-1,2-benzisothiazole are described. The reaction of benzyne with 3-amino-2,1-benzisothiazole afforded N-phenylated products, including N-phenylanthranilonitrile.