Rewiring of Genetic Networks in Response to DNA Damage

TLDR

Genetic networks governing DNA damage responses have traditionally been mapped as static snapshots, despite the dynamic nature of cellular reactions. Comparative analysis of yeast kinase, phosphatase, and transcription factor interactomes during DNA damage showed highly dynamic networks that change with conditions, revealing genetic relationships more effective than static maps for pathway identification. Bandyopadhyay et al.

Abstract

DNA Damage Pathways Revealed Despite the dynamic nature of cellular responses, the genetic networks that govern these responses have been mapped primarily as static snapshots. Bandyopadhyay et al. (p. 1385 ; see the Perspective by Friedman and Schuldiner ) report a comparison of large genetic interactomes measured among all yeast kinases, phosphatases, and transcription factors, as the cell responded to DNA damage. The interactomes revealed were highly dynamic structures that changed dramatically with changing conditions. These dynamic interactions reveal genetic relationships that can be more effective than classical “static” interactions (for example, synthetic lethals and epistasis maps) in identifying pathways of interest.