Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

SH2 domains recognize specific phosphopeptide sequences

Cell · 1993 · 2.7K citations

Protein Function, Signal Transduction, Medicine +7

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

Kun‐Liang Guan, J.E. Dixon · Analytical Biochemistry · 1991 · 1.8K citations

Protein Function, Protein Expression, Biochemistry +10

Crystal structure of the tyrosine kinase domain of the human insulin receptor

Stevan R. Hubbard, Lei Wei, Wayne A. Hendrickson · Nature · 1994 · 1.1K citations

Crystal Structure, Insulin Signaling, Signal Transduction +12

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

Win Ping Deng, Jac A. Nickoloff · Analytical Biochemistry · 1992 · 1.1K citations

Reverse Genetics, Medicine, Genetics +11

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

Andrew C. Chan, Makio Iwashima, Christoph W. Turck et al. · Cell · 1992 · 1K citations

Protein Function, Signal Transduction, Molecular Physiology +12