Loss of Control of Alcohol Use and Severity of Alcohol Dependence in Non‐Treatment‐Seeking Heavy Drinkers Are Related to Lower Glutamate in Frontal White Matter

Abstract

In contrast to the rather unspecific rise in choline-containing compounds, low Glu in frontal WM may be specific for the shift from nondependent heavy drinking to dependence and does not reflect a simple effect of the amount of alcohol consumption alone.