Aminocyclopentadienyl Ruthenium Chloride: Catalytic Racemization and Dynamic Kinetic Resolution of Alcohols at Ambient Temperature

Abstract

Ruthenium–enzyme tandem catalysis: The novel racemization catalyst 1 improves the dynamic kinetic resolution (DKR) of secondary alcohols dramatically. The DKR proceeds at room temperature with isopropenyl acetate as an acyl donor. In addition, the DKR is faster even with much less lipase than in previous DKRs.