New Mechanisms by Which Secretory Phospholipase A2 Stimulates Neutrophils to Provoke the Release of Cytotoxic Agents

Abstract

These data indicate that the sPLA2 can act directly on PMNs to stimulate the release of inflammatory mediators via enzymatic degradation of plasma membrane lipids. In addition, sPLA2 can act as a ligand and stimulate the PMN independently of its enzymatic activity.