Abnormal Reactivity of Muller Cells after Retinal Detachment in Mice Deficient in GFAP and Vimentin

Abstract

Müller cells are subtly different in the GFAP(-/-)vim(-/-) mouse retina before detachment. The end foot region of these cells may be structurally reinforced by the presence of the intermediate filament cytoskeleton, and our data suggest a critical role for these proteins in Müller cell reaction to retinal detachment and participation in subretinal gliosis.