CD49d^-Treg Cells with High Suppressive Capacity are Remarkably Less Efficient on Activated CD45RA^-than on Naive CD45RA⁺Teff Cells

Abstract

Although CD49d(+) Tregs are functional, the suppressive capacity is significantly lower compared to CD49d(-) Tregs. CD45RA(+) Teffs can be completely suppressed, while CD45RA(-) Teffs display relative resistance. Phenotypic and functional heterogeneity of Tregs as well as Teffs has to be considered when analyzing deficiencies in immune regulation.