Regulation of Osteoblast Differentiation by <i>Pasteurella Multocida</i> Toxin (PMT): A Role for Rho GTPase in Bone Formation

Abstract

These results show that PMT inhibits osteoblast differentiation through a mechanism involving the Rho-ROK pathway and that this pathway is an important negative regulator of osteoblast differentiation. Conversely, ROK inhibitors stimulate osteoblast differentiation and may be potentially useful as anabolic agents for bone.