Venous invasion demonstrated by orcein staining of colorectal carcinoma specimens is associated with the development of distant metastasis

Abstract

Elastic stains such as the orcein stain enable the detection of clinically relevant VI with greater frequency than conventionally stained histological slides. If nodal involvement is an indication for systemic chemotherapy, the data presented here suggest that VI detected by the orcein stain should also be an indication for systemic chemotherapy.