Biological Variation in HbA1c Predicts Risk of Retinopathy and Nephropathy in Type 1 Diabetes

Abstract

Between-individual biological variation in HbA(1c), which is distinct from that attributable to MBG, was evident among type 1 diabetic patients in the DCCT and was a strong predictor of risk for diabetes complications. Identification of the processes responsible for biological variation in HbA(1c) could lead to novel therapies to augment treatments directed at lowering blood glucose levels and preventing diabetes complications.