Acute Deficiency of Thyroxine-Binding Globulin during L-Asparaginase Therapy

Abstract

ESCHERICHIA COLI L-asparaginase, an antileukemic agent, acts by hydrolyzing plasma L-asparagine to L-aspartic acid and ammonia, resulting in depletion of plasma L-asparagine levels.1 , 2 Cells susc...