Potent and Selective Inhibition of Class II α‐<scp>D</scp>‐Mannosidase Activity by a Bicyclic Sulfonium Salt

Abstract

Salted away. Shortcomings in the potency and selectivity of natural glycosidase inhibitors, such as swainsonine (1), have led to the proposal of a host of alternative synthetic structural motifs. This paper reports the synthesis of the polyhydroxylated sulfonium salt 2 and demonstrates it to be a potent inhibitor of various human class II α-D-mannosidase activities. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2005/z400397_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.