Gene expression and plasticity in the rat auditory cortex after bilateral cochlear ablation

Abstract

In the cochlear ablation groups, the expression of immediate early genes (Egr1, 2, 3, 4, c-fos, etc.) and neural plasticity-related genes (Arc, Syngr1, Bdnf, etc.) was decreased at 2 weeks and increased at 4 weeks. The expression of neurotransmission-related genes (Gabra5, Chrnb3, Chrne, etc.) was decreased at 12 weeks.