Vitamins C and E Inhibit O ₂ ⁻ Production in the Pig Coronary Artery

Abstract

The present study is the first to show increased O2- production in injured vessels and to demonstrate that antioxidant vitamins reduce O2- production. These results suggest that beneficial effects of antioxidant vitamins in coronary artery disease are related, in part, to alterations in vessel redox state.