Sequential and Modular Synthesis of Chiral 1,3‐Diols with Two Stereogenic Centers: Access to All Four Stereoisomers by Combination of Organo‐ and Biocatalysis

Abstract

Biocompatible: A modular chemoenzymatic synthesis (see scheme) based on asymmetric organo- and biocatalytic reaction sequences allows the sequential construction of both stereogenic centers of 1,3-diols and leads to all four possible stereoisomers in enantiomerically pure form. The biocompatibility of the organocatalytic aldol reaction allows its direct use in the subsequent enzymatic reduction without the need for a work-up step. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.