Concepedia

An Electrophilic Hypervalent Iodine Reagent for Trifluoromethylthiolation

Xinxin Shao, Xue‐Qiang Wang, Tao Yang, Long Lü, Qilong Shen

Angewandte Chemie International Edition · 2013 · 414 citations · 50 references

DOI

Concepts

Abstract

Sulfur and friends: A new electrophilic hypervalent iodine reagent 1 has been developed for direct trifluoromethylthiolation. A variety of nucleophiles, including β-ketoesters, aldehydes, amides, aryl or vinyl boronic acids, and alkynes, reacted with 1 under mild conditions to give the corresponding trifluoromethylthiolated compounds in good to excellent yields.

References

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