Palladium‐Catalyzed α‐Ketone Arylation under Mild Conditions

Abstract

Abstract The α‐arylation of ketones with aryl halides catalyzed by the easily prepared and air‐stable palladium complex (SIPr)Pd(Py)Cl 2 ( 3 ) is described. Complex 3 displays high activity for a variety of aryl halides (activated, unactivated, and sterically hindered aryl halides) under mild conditions. Moreover, both aryl and alkyl ketones can be arylated. The α‐arylation of some alkyl ketones can even be run at room temperature. The mono‐ or diarylated products of the unhindered dialkyl ketone 3‐pentanone could be controlled by temperature and the ratio of ketones to aryl halides.