Publication | Closed Access
THE EFFECT OF ASPIRIN ON THE RESPONSE TO ENDOTOXIN
25
Citations
0
References
1972
Year
InflammationAnimal PhysiologyVeterinary PhysiologyAllergyPlatelet ResponseVascular ResponseAcute Vascular ResponseMedicinePhysiologyVeterinary ScienceSmall Animal Internal MedicineClinical PharmacologyToxicologyPharmacotherapyExperimental PharmacologyPharmacologyToxicological MechanismOxidative Stress
Summary The effect of aspirin on the response to endotoxin in cats, dogs and sheep was studied. Aspirin inhibited the acute vascular response to endotoxin in cats and sheep and the delayed vascular effects in dogs. Aspirin had no effect on the delayed response in cats and sheep. Aspirin had no effect on the platelet response to endotoxin in cats, clogs or sheep. In sheep, aspirin had no effect on the vascular response to 5‐Hydroxytryptamine. In dogs, aspirin significantly inihibited the release of a 5‐Hydroxytryptamine‐like substance by endotoxin from blood and significantly prolonged the half‐life of 5‐Hydroxytryptamine in blood.