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A Histological, Immunological, and Electron Microscopic Study of Bovine Collagen Implants in the Human
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1985
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Tissue EngineeringEngineeringBiomedical EngineeringDermatologyZyderm Collagen ImplantElectron Microscopic StudyMatrix BiologyConnective Tissue DiseaseBovine Collagen ImplantsTheriogenologyAnimal ScienceVeterinary ScienceDermal CollagenWound HealingSoft Tissue ReconstructionMedicineBovine Implant MaterialHuman TissueDermal StructureExtracellular Matrix
The histological fate of an injectable form of type I bovine dermal collagen (Zyderm collagen implant) in the human dermis and subcutaneous tissue has been studied. Sequential biopsies were analyzed by hematoxylin-eosin and Weigert's stains, by immunofluorescence (using a highly specific rabbit anti-Zyderm collagen antibody and a specific anti-human type III collagen antibody), and by electron miscroscopy. The results of this study suggest that the bovine implant material stimulates a host response resulting in implant degradation and replacement by newly generated host collagen.